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Abstract

FORMULATION CHARACTERIZATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF LISINOPRIL BY USING DEHYDRATED BANANA POWDER AS A NATURAL POLYMER

R. B. Saudagar*

ABSTRACT

The purpose of this research was to introduce and evaluate natural excipient that has versatile property in the oral disintegrant and immediate release formulations. This natural excipient was used as disintegrant in the formulation of orodispersible tablets of some model drugs such as lisinopril, Physicochemical studies such as swelling power and solubility, particle size distribution and some other physical evaluations was done on the natural excipient to ensure the suitability to incorporate for such formulation. Five formulations of each drug were formulated in different ratios of natural excipient and Croscaramellose (Superdisintegrant) and the final formulation of all drug used natural excipient alone as binder, diluent and disintegrant. All the formulations are subjected for invitro evaluations such as wetting time, water absorption ratio, invitro dispersion time and disintegration time, etc. Almost same results were obtained on formulations with or without the super disintegrant. Therefore, we conclude that the natural excipient proposed can be used as binder, diluent and disintegrant in oral disintegrating tablets and immediate release dosage forms. Mainly the natural excipient used is biocompatible, cost effective and provides as nutrition supplements.

Keywords: Natural excipient, Patient friendly dosage form, Diluent, Disintegrant, Binder, In vitro stu.


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