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Abstract

FORMULATION AND EVALUATION OF COLON TARGETED CONTROLLED DRUG DELIVERY SYSTEM FOR BALSALAZIDE DISODIUM

Pasupathi A.* and Jaykar B.

ABSTRACT

In the present research work controlled release matrix formulation of balsalazide disodium targeted to colon by using various polymers developed. Balsalazide disodium is delivered intact to the colon where it is cleaved by bacterial azoreduction with pH-dependent solubility. To achieve pH independent drug release of Balsalazide Disodium, pH modifying agents (buffering agents) were used. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets were passed all the tests. Among all the formulations F3 formulation was found to be optimized as it was retarded the drug release up to 24 hours and showed maximum of 99.25% drug release. It followed zero order kinetics mechanism.

Keywords: Balsalazide disodium, Controlled Drug Delivery System, Eudragit L 100 and S 100.


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