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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF NITRENDIPINE

Nayala Firdous* and R. Balaji Reddy

ABSTRACT

The drug delivery via buccal route is considered to be one of the promising alternative to oral route and quick entry of drug into the systemic circulation through the internal jugular vein. The aim of the present investigation was to develop mucoadhesive buccal tablets of Nitrendipine, a calcium channel blocker through buccal route. Mucoadhesive buccal tablets were formulated by direct compression method using mucoadhesive polymers like manugel, acretamer 940 and gum cyamopsis in different ratios. The formulated buccal tablets were evaluated for drug-excipient incompatiblity, precompression parameters (angle of repose, bulk density, hausner's ratio etc.) and post compression parameters like hardness, friability, drug content uniformity and In vitro drug release. Among the 9 formulations, F1, F7 and F8 formulations containing 10mg Manugel, 10 mg and 20 mg Gum cyamopsis respectively were selected for swelling studies, bioadhesion studies and ex vivo permeation studies based on invitro drug release, they showed 96.35, 95.31and 93.48 respectively within 8 hrs. Hence, F1 formulation was optimized. All the 9 formulations showed good flow properties, hardness and friability. The drug release pattern of this formulation was found to be case-II non-fickian and approaching zero order kinetics. Shortterm stability studies of the optimized formulation was carried out and there was no signigicant change in % drug release, drug content and bioadhesion values during 90 days (3 months) at 40±2ºC/75±5% RH.

Keywords: Nitrendipine, Mucoadhesive buccal tablets, calciuum channel blocker, manugel, acretamer 940, gum cyamopsis, bioadhesion strength, swelling index and permeability coefficient.


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