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Abstract

AN IN VITRO RESTORATIVE APPROACH FOR TRISOMY AND MONOSOMY USING GARLIC EXTRACT

Sanyal Debarshi*, Ajinkya Jadhav, Guru Prasad, Geetha Vishwanathan

ABSTRACT

Aim: With the discovery in 1956 that the correct chromosome number in humans is 46, several major chromosomal syndromes with altered numbers of chromosomes were reported, i.e. Down syndrome (DS; trisomy 21), Turner syndrome (TS; 45, X) and Klinefelter syndrome (47, XXY). DS is the commonest autosomal chromosomal abnormality in the newborns and its incidence is 1 in 826 live births. It has been well established that chromosome abnormalities contribute significantly to genetic disease resulting in reproductive loss, infertility, still births, congenital anomalies, mental retardation, abnormal sexual development, and pathogenesis of malignancy. 50% of miscarriages and reproductive loss is contributed by autosomal trisomies in Ist trimester of fetal gestation. Whereas monosomic condition in fetal development leads to spontaneous abortion and so far only 1% survival rate has been reported and the causes of which are unknown. In this study we have taken an in vitro approach to study the response of amniocytes and chorion villi samples on treatment with garlic extract (GE). Main Methods: Our study included 120 samples obtained from amniotic fluid and chrionic villi sampling for studying trisomy 21 and monosomy of X Chromosome . GE (12mg/ml) was added to fibroblast culture, incubated and effect of the same was analyzed by inter phase FISH. Key Findings: Incubation of trisomy and monosomy samples with GE (12mg/ml) has revealed normal chromosomal pattern and is statistically significant (P<0.0001). Significance: Garlic extract seems to have a significant effect on spindle fiber formation and cell division.

Keywords: Aneuploidy, Trisomy, Monosomy, Allium sativum.


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