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*Soraya TEBIBEL1., Chahinez MECHATI1., Saber MESSAOUDI1., Fay├žal NEDJAR2

╣Department of Animal Biology, University of Constantine 1, Algeria
2Laboratory HLA, C. H. U Ben Badis, University of Constantine 3, Algeria


To assess the impact of the HLA system on the couple infertility, a study is realized on 48 couples having presented or not spontaneous repeated abortions. The CROSS-MATCH and the HLA testing (class I and II) are carried out. The result is 9 CROSS-positive MATCH which 7 are accompanied with premature embryonic losses, which can mean that the woman develops antibodies anti paternal HLA. The development of these antibodies is not the only cause of immunological rejection, because in our analyzed population even if the CROSS-MATCH is negative there is always an abortion. In addition, the HLA testing of class II and I informs us about the presence of a HLA homology between parents; in this case, the mother does not consider her embryo (allogeneic) as foreign body. If the spontaneous miscarriages can be explained by classic causes (uterine anomalies, chromosomal and genetic abnormalities, the infectious causes, the hereditary or acquired thrombophilis, the immunological anomalies, the male causes and the environmental factors), some idiopathic and recurrent miscarriages are up to this day without adapted treatment.


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