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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF ONDANSETRON HYDROCHLORIDE

Santosh Girani*, Manish Patel, Mahantesh Kavatekar, Ajay Shahapur, Vital Vijapure

ABSTRACT

The Buccal region offers an attractive route of administration for systemic drug delivery. Ondansetron is a serotonin 5HT 3 receptor antagonist is a potent antiemetic drug, which is used in control of nausea, vomiting associated with cancer chemotherapy. It exhibits only 60-70% of oral bioavailability because of first pass metabolism and has a relative short half-life of 3-5 h. Studies have shown that Ondansetron hydrochloride is well absorbed through the Buccal or sublingual mucosa. Buccal films were prepared using polymers like Chitosan, sodium alginate, HPMC, PVP, PVA. The evaluation parameters like surface pH study, Swelling index, Folding endurance, mucoadhesive strength, Content uniformity, in vitro residence time, in vitro release were observed. The release data were fitted according to release plots, first order, Higuchi’s and Korsemeyer’s equation and the mechanism of drug release was calculated according to Peppas equation and The calculated “n” values suggest that the mechanism of drug release followed class II diffusion transport mechanism. FTIR studies revealed no drug and polymer interaction and uniform amorphous distribution of drug into films. The short term stability studies were done for the formulation MBF6. The drug content and physical appearance was tested but no drastic variationwas observed.

Keywords: Buccal films, Ondansetron hydrochloride, Chitosan, sodium alginate, HPMC, PVP, sodium CMC, PVA. In-Vitro release, FTIR.


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