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Abstract

DESIGNING OF ORODISPERSIBLE TABLET OF METFORMIN HYDROCHLORIDE FOR THE TREATMENT OF TYPE II DIABETES MELLITUS

Chinmaya Keshari Sahoo*1, A.Amulya Reddy2, Vandana Kethavath2 and Prashanth Surabi2, Eshwar Mule2

*1Research Scholar,Osmania University College of Technology, Osmania University, Hyderabad, A.P.-500007
2Princeton college of pharmacy, korremula, Ghatkesar,Ranga Reddy Dist-500388

ABSTRACT

The main aim of the study was to develop orodispersible tablets of Metformin hydrochloride (an an oral antidiabetic biguinide agent) for improving patient compliance,especially those of paediatric & geriatric categories with difficulties in swallowing. In the wet granulation method orodispersible(ORD) tablets were prepared using disintegrants . The prepared batches of tablets were evaluated for weight variation,hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The tablet formulation containing 50 mg of Metformin hydrochloride, 28 mg of lactose, 14 mg of micro crystalline cellulose, 17mg of starch, 8 mg of isapghula husk, 5mg of mannitol, 2mg of talc, 1 mg of mg stearate is considered as the overall best formulation (with an in vitro drug release of 98.2 %) Short term stability studies (at 40±2șC/75±5% RH) on the best formulation indicated that there no significant changes in drug content. From the FTIR study indicated that there are no drug excipient interactions.Undoubtedly the availability of various technologies and the manifold advantages of orodispersible tablets will surely enhance the patient compliance providing rapid onset of action.

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