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Abstract

SYNTHESIS AND IN-VITRO ANTIMICROBIAL ACTIVITY OF SOME NOVEL SUBSTITUTED 1,3,4-THIADIAZOLES

Das Sweety1, Chittur Mohammed Asif Iqbal*2, Janardhanan Saravanan1, Shamanna Mohan1

1Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalroe, India.
2Faculty of Pharmacy, Masterskill Global College, Kuching, Malaysia.

ABSTRACT

A series of new 2-[(substituted benzylidene) imino]-5-(4- methoxyphenyl)-1,3,4-thiadiazoles have been synthesized by the reaction of the thiosemicarbazide with methoxybenzaldehyde to obtaine 2-amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole in the presence of aqueous FeCl3, which was then treated with various substituted aromatic aldehydes to yield the corresponding Schiff bases. The synthesized compounds were characterized by physicochemical and spectral data. All the synthesized compounds were screened for their in-vitro antimicrobial activity by cup plate diffusion method. It can be inferred from the results that the newly synthesized compounds possessing electron withdrawing groups at the aldehydic phenyl ring exhibits better antimicrobial activity than the compounds with electron donating groups.

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