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Abstract

EVALUATION OF ANTIHYPERTENSIVE ACTIVITY ON AQUEOUS LEAVES EXTRACT OF MURRAYA EXOTICA LINN. IN RENAL ARTERY OCCLUDED HYPERTENSIVE RATS

Kanakam Vijayabhaskar*, Kalakota Chaitanya Prasad, Gajavelli Bharath Kumar

ABSTRACT

Aqueous extract of Murraya exotica Linn. (Family: Rutaceae) was evaluated for its antihypertensive activity in renal artery occluded hypertensive rats. Male Wistar rats (180-200g) were pretreated with aqueous extract of Murraya exotica for 6 weeks. Hypertension was induced in animals by clamping the renal artery with renal bulldog clamp for 4 h. Ischemia of the kidneys causes elevation of blood pressure by activation of the renin-angiotensin system. Elevated blood pressure of the animals was significantly (p<0.05) decreased by the aqueous extract of Murraya exotica at the dose levels of 25, 50 and 100mg/kg, i.v. Captopril, angiotensin converting enzyme inhibitor (ACE-I) at the dose of 1 mg/kg, i.v. showed significantly (p<0.05) reduced in the elevated blood pressure. The antihypertensive activity of aqueous leaf extract of Murraya exotica may be due to the action on rennin-angiotensin system.

Keywords: Murraya exotica, antihypertensive activity, rennin-angiotensin system.


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