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Abstract

FORMULATION DEVELOPMENT OF MEDICATED LOZENGES

Nagoba S.N.1* , Rao K.P.2,Ladde S.S1.,Gujrathi D.S.1

1Shivlingeshwar College of Pharmacy, Almala,Latur,Maharashtra,India
2H.K.E.s College of Pharmacy, Gulbarga (Karnataka) India

ABSTRACT

Clotrimazole was formulated as a medicated lozenge to provide slow release medicament for the treatment of oral thrush in pediatric patients. There are dosage forms like syrups, tablets in the market but still there is a need for new dosage forms which acts effectively and locally. So the present investigation aims to design, prepare and evaluate medicated lozenge of Clotrimazole. The benefits of these prepared medicated lozenges are increased bioavailability, reduction in gastric irritation by passing first pass metabolism. The medicated lozenges were prepared by heating and congealing method in a candy based industry on request using sucrose as base. All the formulations prepared were subjected to various physico-chemical parameters like hardness, content uniformity, moisture content, weight variation, thickness & diameter etc. The prepared formulations have a hardness of 10.5-11.5 Kg./cm, free from gritty particles, and good taste. Stability study of selected formulations were stored at 302C/655%RH, elevated 402C/755%RH for a period of six months. Selected formulations were tested for drug excipient interactions subjecting to IR Spectral analysis. Invitro drug dissolution studies showed 90.36% for C1, 88.25% for C2, 82.22% for C3, and 68.64% for C4, release of drug in 30 minutes, 98.21% in 15 minutes from C0 formulation. The prepared medicated lozenges were subjected for antimicrobial activity on causative organisms collected from a diseased patient under the supervision of ethical committee. Clotrimazole showed the zone of inhibition 24.00mm and pure Clotrimazole showed 22.33mm of zone inhibition. Thus the lozenges can provide an attractive alternative formulation in the treatment of oral thrush in pediatric patients.

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