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Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL SUSTITUTED [1,2,4]TRIAZOLO[5,1-b][1,3,4]THIADIAZOLE DERIVATIVES

Musmade Deepak S.*, Pattan Shashikant R., Manjunath S. Yalgatti and Vikas B. Gawali

ABSTRACT

The search for potent bioactive agents in pharmaceutical industry has been directed towards the nitrogen containing heterocycles. In recent days the researchers think about synthesis of bridged derivatives of nitrogen containing heterocycles. The present study reports the synthesis of a library new conjugated heterocycles including [1,2,4]triazolo[5,1-b][1,3,4]thiadiazoles by cyclo condensation reaction of 1-amino-3-aryl-1H-1, 2, 4-triazole-5-thiol with various aromatic carboxylic acids and phosphorous oxychloride. The structures of newly synthesized compounds were established using IR, 1H-NMR, Mass and elemental analysis. The newly synthesized compounds were screened for antimicrobial activity using cup-plate agar diffusion method some of the compounds shows promising antibacterial and antifungal activity.

Keywords: Antibacterial, anti fungal activity, [1,2,4]triazolo[5,1- b][1,3,4]thiadiazole.


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