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Abstract

EVALUATION OF HIGH VISCOSITY GRADES OF HYPROMELLOSE FOR THEIR POTENTIAL APPLICATION AS POLYMERS IN GASTRORETENTIVE DRUG DELIVERY SYSTEM

Dr. Rajashree Hirlekar*, Palak Phansalkar and Omkar Mainkar

ABSTRACT

Polymers are an important formulation consideration for Gastroretentive Drug Delivery System (GRDDS) as the polymers play an important role in allowing the dosage form to remain in gastrointestinal tract for a longer time thus enabling the required quantity of drug to be released and absorbed into the body. The objective of this study was to compare swelling, water uptake[1] and water holding capacity of commonly used grades of Hypromellose (Hydroxypropylmethyl cellulose) for their potential application as polymer for GRDDS. The study found that K100M grade of Hypromellose provided the best results which could facilitate its use as polymer in GRDDS.

Keywords: Hypromellose, GRDDS, polymers.


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