WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

EFFECT OF FRACTION 1 OF PORTULACA OLERACEA ON HEMATOLOGICAL AND PLASMA BIOCHEMICAL PARAMETERS IN MALE WISTAR RATS

Oyedeji Kazeem Olusina*, Adegoke Olajire, Oladosu Adebayo, Abidoye Dele

ABSTRACT

Portulaca oleracea is a fleshy annual herb which is distributed throughout temperate and tropical areas of world. The crude extracts of this plant have been reported to have toxic and beneficial effects on hematological functions and blood chemistry in male rats. Air-dried specimen of Portulaca oleracea was cold-extracted in methanol for 72 hours. The resulting methanol extract was then subjected to open column chromatography on silica gel for fractionation. Out of the 5 fractions obtained, fraction 1 was then subjected to male rats’ hematological and plasma biochemical bioassays. Twenty male rats (160 – 180 g) were divided into control (distilled water) and fraction 1 (1, 2, 3, mg/kg) treated groups (5 per group). The animals were orally treated on daily basis for 30 days. Red Blood Cell (RBC) and Total White Blood Cell (TWBC) counts were determined using hemocytometer. Activities of plasma Alanine Amino Transferase (ALT), Aspartate Amino Transferase (AST) and levels of total protein, globulin and albumin were determined by spectrophotometry. Treatment of rats with fraction 1 (2 mg/kg) produced significant (p<0.05) reductions in PCV and monocyte values relative to their respective controls. Fraction 1 (2 mg/kg, 3 mg/kg) caused significant (p<0.05) increase in total protein and globulin levels relative to their respective controls. It can therefore be concluded that fraction 4 of Portulaca oleracea probably has both toxic and beneficial effects on hematological functions and blood chemistry in male rats.

Keywords: Fraction 1, Red blood cell, Total white blood cell, Albumin, Rats.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More