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Abstract

FORMULATION AND INVITRO EVALUATION OF NIFEDIPINE EFFERVESCENT FLOATING MATRIX TABLETS BY USING HYDROPHILIC POLYMERS

Pamu Sandhya* and Taiyaba Fatima

ABSTRACT

In the present work, an attempt has been made to develop gatroretentive effervescent floating matrix tablets of nifedipine by using hydrophilic polymers such as Gum Cyamopsis, Xanthan gum and Sodium alginate as retarding polymers. The polymers are used in different ratios, all the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters such as hardness, thickness, friability, percent drug content, weight variation tests and they passed all the quality control evaluation parameters as per I.P limits. Sodium bi carbonate concentration is optimized by trails, we found 20% is optimum to obtain required floating lag time (22.9 seconds) and total floating time (≥12 hours). Among all the formulations F3 formulation showed maximum percent drug release i.e., 99.86% in 12 hours. Hence it is considered as optimized formulation with the optimum concentration of polymer. It was observed that the 1:30 ratio of gum cyamopsis has distinct effect on in vitro drug release profiles up to 12 hours, when compared to all the other ratios of polymers. Drug release kinetics followed Zero order.

Keywords: nifedipine, floating matrix tablets, Gum Cyamopsis, Xanthan gum, Sodium, floating lag time, total floating time.


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