WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

EFFECT OF RECOVERY PERIOD ON REPRODUCTIVE FUNCTIONS IN MALE WISTAR RATS TREATED WITH FRACTION 1 OF PORTULACA OLERACEA

Oyedeji K. O. , Oladosu I. A., Adegoke Olajire

ABSTRACT

Objective: To investigate the effect of recovery period on reproductive profiles in male rats treated with fraction 1 of Portulaca oleracea. Methods: Air-dried specimen of Portulaca oleracea was coldextracted in methanol for 72 hours. The resulting methanol extract was then subjected to open column chromatography on silica gel for fractionation. Out of the 5 fractions obtained, fraction 1 was then subjected to male rats’ reproductive bioassays. Twenty male rats (120- 150 g) were divided into control (distilled water) and fraction 1(1, 2, 3 mg/kg) treated groups (5 per group) for hormonal assay and andrological studies. The animals were orally treated on daily basis for 50 days and allowed a recovery (withdrawal) period of 50 days after which plasma testosterone level was assayed using Enzyme-Linked Immunosorbent Assay (ELISA) and semen analysis was done microscopically. Results: There were significant (p<0.05) decrease in sperm motility of fraction 1(1 mg/kg, 2 mg/kg, 3 mg/kg) recovery groups relative to control. Also, there were significant (p<0.05) decrease in sperm counts of fraction 1(1 mg/kg, 2 mg/kg) recovery groups relative to the control. Conclusion: It can therefore be concluded that the deleterious effects induced by chromatographic fraction 1 of Portulaca oleracea on the reproductive parameters in male rats were probably irreversible.

Keywords: Fraction 1, Recovery, Sperm motility, Sperm counts, Rats.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More