FORMULATION AND EVALUATION OF MUCOADHESIVE BILAYER BUCCAL TABLET OF SUMATRIPTAN SUCCINATE
Manisha R. Pundge*, Prafull P. Patil, Dr. Shashikant D. Barhate
ABSTRACT
Objective: To develop mucoadhesive bilayer buccal tablet of
Sumatriptan succinate as controlled release tablet to enhance its
bioavailability and reduce its frequency of dose. Method: Sumatriptan
succinate tablets were prepared with natural mucoadhesive polymer
Sodium alginate, alone had the bioadhesive forces suitable for buccal
bioadhesive tablets, with slightly reducing its strong mucoadhesive
property by addition of HPMC,to prevent from damaging of skin due
to strong mucoadhesive property of Sodium alginate.50mg backing
layer compressed to control the release of drug from tablet. Ideal batch
shows maximum mucooadhesive time and maximum mucoadhesive
strength of 13.10g Results : The selected batch F3 and F6 shows
maximum releas up to 99% and 98% in 6hrs. Conclusion:
Mucoadhesive bilayer buccal tablet of Sumatriptan succinate improve
bioavailability. A combination of polymer Sodium alginate: HPMC shows good drug release
as compaire to other batches.The ratio of both polymer was taken as 2:1 showing maximum
drug release. These both polymer combinations show good mucoadhesive strength, good
permeation also.
Keywords: Bilayer buccal tablet of Sumatriptan succinate, mucoadhesive strength, Sodium alginate, in vitro permeation study.
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