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Abstract

HEPATOPROTECTIVE ACTIVITY OF ETHANOL EXTRACTS OF PHALLUSIA NIGRA AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS

*D. Shanmuga Priya, H. Kohila Subathra Christy, S. Sankaravadivu

ABSTRACT

Ascidians are marine sedentary organisms. Phallusia nigra is a simple ascidian belonging to the family Ascidiidae. The present study was designed to screen and evaluate the hepatoprotective activity of ethanol extracts of Phallusia nigra against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP and bilirubins. Silymarin, a known hepatoprotective drug is used for comparison. The animal extracts were effective in protecting liver against injury induced by CCl4 in rats.

Keywords: Phallusia nigra, hepatoprotective activity, Silymarin.


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