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Abstract

DEVELOPMENT AND CHARACTERIZATION OF ATENOLOL FAST DISSOLVING ORODISPERSIBLE FILMS

Amit B. Patil*, R. Narayana Charyulu, C. S. Shastry

Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences. Paneer, Deralakatte. Mangalore 575 018. India.

ABSTRACT

The present research work aims at development of fast dissolving orodispersible films of sparingly water soluble atenolol with the purpose of developing rapid onset of action. Atenolol is β1 blocker, prescribed widely in diverse cardiac abnormalities. Literature reports that faster disintegration leads to optimum drug release resulting in higher bioavailability. The present research work attempts to correlate the effect of concentration of pullulan and solubilizing agent on the disintegration time and drug release profile. Pullulan and tween 80 were used as film forming polymer and solubilizing agent respectively. The films were prepared by solvent casting method and characterized. The optimum concentration of plasticizer and solubilizing agent was developed on the basis of flexibility, tensile strength and stickiness of the film. Fast dissolving films showed optimum drug content and folding endurance. The disintegration time of formulation PUT7 film was found to be 10 sec with in vitro release of 100% in approximately 90 sec, which was better than other prepared formulations. Drugexcipients interaction studies performed using FTIR; showed no interaction. Surface pH was found to be neutral, indicating safety of administration. Accelerated stability studies showed no change in the physicochemical properties of all the formulated films. Thus the objective to formulate atenolol fast dissolving orodispersible films was successfully achieved.

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