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Abstract

DEVLOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERE OF RALOXIFENE HYDOCHLORIDE.

Abhishek Mishra*, Dr. Shamim Ahmad, Vandana Singh, Hariom Sharma

ABSTRACT

Muccoadhesive chitosan microspheres of Reloxifene were prepared for oral administration with the aim of avoiding the first pass effect and improve the bioavaibility. A series of batches of microspheres were prepared by emulsion solvent diffusion technique in which drug to polymer ratio was used to prepare the different formulation. The microspheres were evaluated for physical characteristics such as particle size, particle shape and surface morphology by scanning electron microscopy, drug entrapment efficiency, in vitro mucoadhesion, and in vitro drug release characteristics. The microspheres had a mean particle size of 36.47 + 3.39 mm, suitable for administration. Electron microscopy revealed that microspheres were spherical with nearly smooth surface morphology. Application of in vitro drug release data to various kinetic equations indicated matrix diffusion controlled drug release from chitosan microspheres.

Keywords: Mucoadhesive microsphere, raloxifene hydrocloride, bioavaibility.


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