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Abstract

HEPATOPROTECTIVE EFFECT OF POLYHERBAL FORMULATION “MENTAT” AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS

Chetan Rastogi, Syed Anees Ahmed, Dr. Talha Jawaid*, Rajan Awasthi, Kalpana, Mehnaz Kamal

ABSTRACT

Hepatotoxicity implies chemical-driven liver damage. Certain
medicinal agents, when taken in overdoses and sometimes even when
introduced within therapeutic ranges, may injure the organ.The current
study was done to investigate the hepatoprotective effect of Polyherbal
formulation Mentat against CCl4 induced hepatotoxicity in rats.
Sprague-Dawley rats (male) weighing 200-250 g was used.
Hepatotoxicity was induced by administration of 50% CCl4 in olive oil
intraperitoneally every 72 hr for 10 days. Silymarin was used as
standard in dose of (0.5 ml/100 g b.w.) and the test drug Mentat was
used in dose of (2 ml/kg) was orally administered before or after CCl4
treatment in various groups. Serum glutamic oxaloacetic transaminase (SGOT), Serum
glutamic pyruvic transaminase (SGPT), Alkaline phosphatase (ALP), Total bilirubin (TB)
parameters were estimated. Serum SGOT, SGPT, ALP and TB activities significantly
decreased (p < 0.05) as compared to CCl4 treated group. The present study demonstrated that
Mentat possesses hepatoprotective effects against CCl4 induced hepatotoxicity and that the
effects are both preventive and curative.

Keywords: Carbon tetrachloride, SGOT, SGPT, ALP, TB, Mentat, Silymarin.


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