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Abstract

CARCINOSIN 30 C PROTECTS ISLETS AGAINST STZ INDUCED BETA CELL DYSFUNCTIONS

Ramakrishna Dandanayakula, Nagasuryaprasad Kotikalapudi, Venu Gopal Gouri, Suresh Pothani and Vijayalakshmi Venkatesan*

ABSTRACT

Diabetes mellitus is a chronic metabolic syndrome precipitating with several secondary complications. Despite enormous progress in conventional medicine, there is still ambiguity in line of treatment to maintain glucose homeostasis. In this context, homeopathic treatment forms viable and an alternative option in the management of hyperglycemia and has demonstrated beneficial effects in the management of inflammatory diseases including diabetes which reflects state of profound stress and inflammation. The present study addresses the role of Carcinosin 30 c a homeopathic formulation to measure the islet cell function and we have measured cell viability (MTT, LDH leakage), oxidative stress/ inflammatory (ROS, mRNA for TNF-α /and IL-6, Insulin), insulin secretion from Normal and STZ induced diabetic mice. To test our hypothesis, study design included isolation and maintenance of primary islet cell cultures from Normal and STZ mice (>500mg /dl) primary islet cells were divided into four Groups as: A (Control), B (STZ per se), C (Control + Cacinocin 30 c) and D: (STZ per se + Carcinosin 30 c), incubated for 48 hours under optimal conditions in RPMI medium. Our results demonstrated beneficial effects of Carcinosin 30 c against the STZ treated islets and almost reversed cell viability, reduced free radical generation (ROS) and inflammation (TNFα IL-6) with IL-6 being more significant in addition,restored insulin secretion (5.5 and 16.5 mM) compared to STZ per se(Group B). Based the impetus obtained from the present studies (cytoprotective, insulinotrophic, anti-inflammatory/stress) by Carcinosin 30 c against STZ treatment ,its feasible application in the management of diabetes can be explored.

Keywords: Carcinosin 30 c, Islets, STZ, cytoprotection, insulinotrophic.


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