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Abstract

SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL ACTIVITY OF (E)-N'-(SUBSTITUTED-BENZYLIDENE) -2-(2-CHLORO-4-FLUOROPHENYL) ACETOHYDRAZIDE DERIVATIVES

Birendra Kumar*, A.K. Mishra, Manju Kumari, Neha Singh, Binita Kumari, G.Srinivas

ABSTRACT

The present paper describes the synthesis of (E)-N'-(3,4,5- trimethoxybenzylidene)-2-(2-chloro-4-fluorophenyl)acetohydrazide derivatives 4a-k, prepared in a three-steps from commercially available 2-(2-chloro-4-fluorophenyl)acetic acid 1. The structural determination of the newly synthesized acetohydrazide-hydrazones was confirmed by analytical tools like 1H NMR, mass and IR. These compounds were evaluated against a panel bacterial and fungal pathogens such as Gramā€positive (Staphylococcus.pyogens and Staphylococcus aureus),Gramā€negative (Escherichia coli and Pseudomonas .aeruginosa) and Aspergillus niger and Candida albicans with reference to Chloramphenicol and Nystatin as the standard drug. Compounds 4a-k showed moderate to good antibacterial activity but displayed weak fungal activity.

Keywords: Acetohydrazides, Antibacterial activity, Hydrazones, Chloramphenicol, Rotamers.


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