Abstract

COMPERETIVE STUDY OF FURAZOLIDONE AND FURAZOLIDONE WITH PHYTOCONSTITUENTES ON BROILER CHICKEN

Arvind Sharma* and Shashi Ranjan

ABSTRACT

Furazolidone is reduced at the nitro group in the initial step of their biotransformation, and continued to undergo further reduction of the nitro. It has been suggested that the nitro-reductive intermediates of nitrofuran derivatives are genotoxic, still farmers are giving this antibiotic for the treatment of diarrhea to chicken in many countries. To reduce the effect of furazolidone Natural herbs and formulations researchers formulated a product contains furazolidone in addition with various Phytoconstituents extracted from various herbal plants and studied under various treatments on broiler chicken. This study revealed that Furalac+ reduced the furazolidone metabolic rate in chicken and inhibited the activity of NADPH cytochrome P450 reductase (CPR) was responsible for the increasing of the furazolidone metabolic rate. Our research also revealed that being a less carcinogenic effect product has more than 200 g/mol furazolidone activity against diarrhea and showed best FCR.

Keywords: Cancer, FCR, Furazolidone, Furalac+, Oocyst.