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Abstract

FORMULATION AND EVALUATION OF THE SUCKABLE CHEWABLE MEDICATED LOLLIPOPS OF VENLAFAXINE Hcl

M.. Prathap*, Dr.. Subhranshu Panda and A.. Anusha

ABSTRACT

There are several dosage forms in the market, there is a need for more dosage form which acts effectively and locally as well as systematically. The benefits of the present research work is increased retention time of the dosage form in oral cavity and increased bioavailability, reduction in gastric irritation by passing first pass metabolism. Lollipops are flavored medicated dosage form intended to be sucked and held in the mouth or pharynx containing one or more medicaments usually in the sweetened base. Medicated lollipop is designed to improve patient compliance, acceptability. The lollipops were prepared by heating and congealing method using methylcellulose, citric acid as polymer. Drug Venlafaxine Hcl is an antidepressant drug which contains very bitter taste drug. For patient acceptability we need to improve the taste of the drug by different saccharieds like sucrose, dextrose, maltose, lactose, mannitol, Pourability ,Texture,and Elasticity is improved by different plasticizers like glycerin, propylene glycol, PEG 600.It was found that the formulation containing methyl cellulose,and combination of sacharides like dextrose,sucrose showed better drug release and it was more stable, unlike the other formulations. Accelerated stability study conducted as per ICH guidelines at 45 ºC and 75% relative humidity over a period of one month found that there wasn’t any substantial interaction between the drugs, flavour and colour and the prepared formulation were stable.

Keywords: Lollipop, Venlafaxine Hcl, Sacharides, Platiciizers.


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