WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DISSOLUTION ENHANCEMENT AND COMPARATIVE ASSESSMENT OF MICROCAPSULE LOADED SUSTAINED RELEASE MUCOADHESIVE GASTRO RETENTIVE TABLETS WITH AVAILABLE MARKETED FORMULATIONS

Ashani Basu*, Aisha Khanum, Shaikh M, Suraj Choudhary, Rachel C

ABSTRACT

Losartan potassium is a non-peptide molecule and selective competitive angiotensin II type 1 receptor (AT1) receptor antagonist which is mainly used as a first line treatment for the patients suffering from hypertension. In the present research work Losartan potassium loaded microcapsules were fabricated by using modified double emulsion solvent evaporation method and further more they were incorporated into mucoadhesive gastro retentive tablets. The release kinetic of the prepared tablets was evaluated by using PCP Disso V3® software and it selected ‘zero order’ model as the best fitting model, supporting the sustained release property of the final oral dosage forms which was the primary objective of the present study. Final formulations were subjected to comparison with three different marketed conventional dosage forms on the basis of dissolution property and it showed better release pattern than the rest.

Keywords: Losartan potassium, PCP Disso V3, Kinetic models, Microcapsules, Eudragit.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More