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Abstract

EVALUATION OF ANTHELMINTIC ACTIVITY OF FICUS BENGHALENSIS LINN ROOT EXTRACTS

Lokesh K. Bhardwaj* and Dr. Kaushal K. Chandrul

ABSTRACT

The increasing use of synthetic drugs are very effective in curing the disease but have a number of side effects and high cost of synthetic medicines has created an interest in studying the medicinal plants as an alternative source of synthetic medicines. Crude drugs, are obtained from plants are less effective with respect to cure of disease but herbal drugs are relatively free from side effects. The objective of this study was to evaluate the anthelmintic efficacy of root extracts of Ficus benghalensis Linn. (Banyan Tree ) against Pheretima posthuma and Ascardia galli. All the extracts were used as test solutions. Piperazine citrate was included as standard drug and normal saline as control. Three concentrations 25mg/ml, 50mg/ml, 100mg/ml of each extract and standard drug at the concentration of 25mg/ml were studied. Observations were made for the time taken to paralyze and death of the earthworm. Significant anthelmintic effects of crude extracts on live worms were observed in terms of the paralysis and death of the worms. However, ETE and AQE were more efficacious than CHE and PTE. The results showed ETE demonstrated paralysis at 4.25 min and death at 8.9 min of worms in shortest time as compared to piperazine citerate, paralysis at 4.0 min and death at 8.06 min especially at higher concentration of 100 mg/ml in case of Pheretima posthuma. While in case of Ascardia galli ETE showed paralysis at 6.68 min and death at 9.98 min. AQE caused paralysis of Pheretima posthuma and Ascadia galli in 5.18 min and 8.03 min and death at 11.26 min and 11.28 min respectively.

Keywords: Anthelmintic, Piperazine citrate, Ficus benghalensis, Pheretima posthuma.


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