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Abstract

AN IN VITRO INVESTIGATION OF AMELIORATIVE EFFECT OF SYNTHETIC AND HERBAL ANTIOXIDANTS ON LEAD INDUCED NEUROTOXICITY

Flora Shah* and Nayan Jain

ABSTRACT

Lead is one of the ubiquitous and dangerous occupational as well as environmental toxicants of global concern. Due to its capacity to act as potent systemic toxicant, it is the present need to investigate different ameliorative techniques for prevention of lead toxicity through proper understanding of molecular mechanisms. Present study deals with in vitro system of investigation of ameliorative effect of specific synthetic antioxidants especially, N-acetyl cysteine (5.5 mM/kg/day), Ascorbic acid (200 mg/kg/day), Tocopheryl acetate 160 mg/kg/day) and Thiamine (30 mg/kg/day) as novel combinational therapy approach as well as Bacopa monnieri (10 mg/kg/day) as herbal antioxidant therapy against lead induced neurotoxicity. The current synergistic study involves culturing of goat brain in DMEM: F12 (1:1 mixture) culture media containing 1 ppm lead acetate along with administration of selective antioxidants at prescribed dosage for 6-hrs. Selective biochemical parameters such as Lipid Peroxidation, Protein Levels, Alkaline Phosphatase, Acid Phosphatase, Succinate Dehydrogenase, Adenosine Triphosphatase and Superoxide Dismutase activities were analyzed and observed for protection against lead intoxication. Results indicate significant alteration in all biochemical parameters studied in lead exposed cultures as compared to control. Total and Soluble Proteins, Alkaline Phosphatase, Succinate Dehydrogenase, and Adenosine Triphosphatase showed significant reduction while Lipid Peroxidation, Acid Phosphatase and Superoxide Dismutase activities increased significantly in lead exposed cultures as compared to control. Results also emphasized that simultaneous administration of prescribed antioxidants and lead in cultures manifested maintenance of all biochemical parameters studied and strongly suggest that synthetic and herbal antioxidants therapy can confer protection against lead induced neurotoxicity in mammals.

Keywords: Lead Toxicity, Synthetic Antioxidants, Herbal Antioxidant, Bacopa monnieri extract, Neurotoxicity, Oxidative Stress.


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