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Abstract

ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIMICROBIAL PROPERTIES OF NEW LECTINS PURIFIED FROM ROOTS OF ALGERIAN PLANTS: MORUS NIGRA, RUTA GRAVEOLENS, CYPERUS ROTUNDUS AND PISTACIA LENTISCUS.

Ahlem Bahi, Youcef Necib*, Fateh Merouane, Hala Bouadi and Khaled Boulahrouf

ABSTRACT

In this work, the use of desialylated stroma from erythrocytes represented the cheapest method to purify the lectins. To evaluate the antioxidant potential of lectins purified from roots of Morus nigra, Ruta graveolens, Cyperus rotundus and Pistacia lentiscus, in vitro antioxidant activities of lectins using DPPH, SOD, Fe+3 reducing assay, H2O2 scavenging and lipid peroxydation inhibitions were carried out. DPPH, SOD and Fe+3 assays showed that lectins purified from root of Morus nigra, Ruta graveolens, Cyperus rotundus and Pistacia lentiscus significantly reduced DPPH, SOD and Fe+3 free radicals with the low IC50 value observed in Morus nigra (115.34, 211.11 and 281.25 μg/ml) and in Ruta graveolens (208.95, 158.75 and 116.2 μg/ml) respectively compared to standard ascorbic acid. Furthermore, the purified lectins of Morus nigra and Ruta graveolens showed highest reducing of H2O2 and lipid peroxidation inhibition (LPI) with IC50 value 98.76, 27.27 and 163.04, 36.40 respectively compared to standard ascorbic acid. Another hand, purified lectins of Morus nigra, Ruta graveolens, Cyperus rotundus and Pistacia lentiscus showed a significant reduction in the edema paw volume and presented a highly activity antimicrobial. The lectins isolated from roots of Morus nigra, Ruta graveolens, Cyperus rotundus and Pistacia lentiscus relieved that it was capable of scavengenging the free radical and exhibit antifungal, antimicrobial and anti-inflammatory activity.

Keywords: purified lectins, antioxidant, anti-microbial, anti-inflammatory.


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