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Abstract

DEVELOPMENT AND VALIDATION OF EFAVIRENZ IN BULK DRUG AND FORMULATION BY RP-HPLC METHOD

Haneef1, Humera sultana1, Tharun goud1, Pavan Kumar Pindi2*

1Department of Pharmaceutical sciences, University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar
2Department of Microbiology, Palamuru University, Mahabubnagar, India-509001

ABSTRACT

Aim: A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validation of Efavirenz in its pure form as well as in tablet dosage form. Method: Chromatography was carried out on a symmetry C18 (4.6 x 150mm, 5μm) column using a mixture of methanol and phosphate buffer (65:35 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 245 nm. Results: The retention time of the drug was 2.48 0.02min. The method produce linear responses in the concentration range of 20-80mg/ml of Efavirenz. The method precision for the determination of assay was below 2.0% RSD. Conclusion: This method is useful in the quality control of bulk and pharmaceutical formulations.

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