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Abstract

ANTI-INFLAMMATORY EFFECTS OF NIGELLA SATIVA L. MELANIN

Adila El-Obeid*, Kamal Eldin H. ELTahir and Adil M. Haseeb

ABSTRACT

Herbal melanin, obtained from Nigella sativa L., has been studied for anti-inflammatory effects against formalin-induced rat-paw oedema. Topical treatment with 2.5% melanin solution has significantly inhibited the swelling (compared to untreated induced-oedema swelling) to 75.4% after 1hr, 81.1% after 2hr and 85.6% after 3hr. Treatment with 1% hydrocortisone solution reduced the inducedoedema swelling after 1, 2 and 3hr to 32.7%, % 63.1 and % 71.9% respectively. The melanin treatment has shown a rapid and effective reduction of the induced-oedema.

Keywords: Nigella sativa L.; Herbal melanin; hydrocortisone; paw oedema.


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