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Shivaji Vasudeo Shinde* and Ritesh Suresh Bathe


Gabapentin was introduced in 1994 as an adjuvant antiepileptic drug. Of late, it has found applications as a broad spectrum analgesic and as a multimodal peri-operative drug. The absorption of Gabapentin is dose dependent due to a saturable transport system. It is extensively distributed in human tissues & fluids after oral administration. It does not bind to plasma proteins & is not metabolized. The elimination halflife after a single oral dose is 5-7hrs. It crosses the blood brain barrier rapidly. So the floating tablet formulations are needed for Gabapentin to prolong its duration of action, to increase its oral bioavailability and to improve patient compliance. Many methods are used for preparing floating tablet preparations of Gabapentin by using various grades of Hydroxypropyl methyl celluloses (HPMC K4M, K15M, K100M) at various concentrations 10%, 20% and 30%. This review article comprises of the research materialized in the field of formulation and evaluation of floating tablets of Gabapentin.

Keywords: Oral Route, Gastroretentive, Floating Tablets, Gabapentin, HPMC, Antiepileptic.

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