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Abstract

CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEWLY SYNTHESIZED BENZIMIDAZOLYL COMPOUNDS WITH DOCKING STUDIES

*Senthamizh Selvan N., Agalya R., *Maruthamuthu, Shameela Rajam, Christina Ruby Stella P.

ABSTRACT

In an effort to establish new candidates with improved antimicrobial activity, [2-(1H-benzo[d]imidazol-2-yl)-phenyl]-benzylidene amine and 2-[2-(1H-benzimidazol-2-yl)-phenylimino]-methyl phenol were synthesized, characterized and evaluated for antimicrobial activity. The desired compounds were synthesized by the condensation of benzene- 1, 2-diamine with 2-aminobenzoic acid. Compounds were characterized by IR, 1H-NMR, 13C- NMR and elemental analysis. They were also screened for antimicrobial activity against Staphylococcus aureus and Aspergillus niger. Docking was performed by using DICLOFENAC bound to COX2 to understand the binding preference of the synthesized compounds with target protein. The compound [2- (1H-benzo[d]imidazol-2-yl)-phenyl]-benzylidene amine shows higher antimicrobial activity and is found to fit well with the binding sites of the target protein.

Keywords: Synthesis, Antimicrobial, Docking, benzene-1, 2-diamine, 2-aminobenzoic acid.


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