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Dr. Manjunath H.*, Dr. Shashikala G H, Dr. Somashekar H S, Dr. Babool Raj and Dr. Prashanth D


Objective: To compare the efficacy of opipramol and escitalopram in the treatment of generalized anxiety disorder. Materials and Methods: The study was conducted in outpatients (18 to 65 years old) of psychiatry department, diagnosed with Generalized Anxiety disorder (GAD) according to DSM-IV criteria. Total of 96 patients were included in the study with 50 patients receiving opipramol 50mg once daily and 46 escitalopram 5mg. The efficacy was assessed using Hamilton Anxiety Rating Scale (HAM-A) at the baseline and after 4 weeks. Paired t-test was used to assess difference between before and after treatment within the groups. To assess difference between the groups unpaired T-test was used. p value of <0.05 or less was considered for statistical significance. Results: Mean changes in HAM-A scores from baseline to 4 weeks within group for opipramol and escitalopram was highly significant (p < .000). Between opipramol and escitalopram treated group there was no significant difference in mean total HAM-A scores (p .85). All the adverse events in both the group were mild to moderate. Conclusion: Opipramol is effective in the treatment of GAD and it is as effective as escitalopram.

Keywords: Opipramol, esitalopram, Generalized anxiety disorder, HAM-A.

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