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Abstract

DEVELOPMENT OF AGGLOMERATED CRYSTLAS OF IRBESARTAN BY SPHERICAL CRYSTALIZATION TECHNIQUE FOR ENHANCING THE MICROMERITIC AND SOLUBILITY PROPERTY

Kotta Kranthi Kumar*, Dr. Pankaj Kumar Sharma, Dr. L. Srinivas

ABSTRACT

Irbesartan practically insoluble in water. The present aim of the work is to increase the solubility by spherical crystallization method and convert into a tablet. N, N dimethyl formamide as a good solvent, bridging solvent chloroform & bad solvent water was selected. Spherical crystals are prepared by using β-cyclodextrin and HP-β- cyclodextrin in various ratios by quasi emulsion solvent diffusion method spherical agglomerates are prepared and converted into orodispersible tablets by direct compression technique. Various super disintegrating agents (SSG, Croscarmalose and crospovidone) F36 of 1:3 rations shown high dissolution efficiency of 98.09%. ANOVA significance value of P<0.05 which will indicates the co-processing parameters variability within the specified limits.

Keywords: Irbesartan and crospovidone.


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