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Abstract

KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FOSINOPRIL SODIUM ANTIHYPERTENSIVE DRUG IN PHARMACEUTICAL FORMULATIONS

٭H.M. Elqudaby

ABSTRACT

A simple kinetic spectrophotometric method has been described for the determination of fosinopril sodium (FOS) antihypertensive drug. The method depends on oxidation of the studied drug with alkaline potassium permanganate in presence of sodium hydroxide to produce a bluish- green colored species. The reaction is followed spectrophotometrically by measuring the rate of change of absorbance at room temperature for a fixed time of 10 min. The absorbance of the colored manganite ion is measured at 610nm. Beer's low is obeyed over the concentration range 2-30μgml-1FOS using fixed time method. The relative standard deviation is 2.0 % for 5 replicates of 10μgml-1 of FOS. The results are validated statistically and checked through recovery studies. The method has been successfully applied for the determination of the studied drug in commercial dosage forms. Statistical comparison of the results with the reference methods show excellent agreement and indicate no significant difference in accuracy and precision.

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