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Abstract

EFFECT OF BODY MASS INDEX ON BIOCHEMICAL AND HEMATOLOGICAL PROFILES IN POSTMENOPAUSAL WOMEN WITH BREAST CANCER

Haedar abdulhafith Al-biati, Ahmed salih sahib* ,Anwar Noori Mahmood


ABSTRACT

Background: Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset. However, little is known about the effect of obesity on treatment efficacy. Women who are obese continue to have higher levels of estrogen than women of normal weight even after treatment with hormone- suppressing drugs ,raising the possibility that they might benefit from modification or changes to their treatment. Objective: The aim of this work is to study the effect of body mass index on biochemical, hematological, trace elements, and estrogen level of obese and non-obese Iraqi postmenopausal women with breast cancer in comparison with postmenopausal obese and nonobese women who had no breast cancer. Material and Methods: A hospital based case control study was carried out at Baquba Teaching Hospital, Diyala, Iraq. The analysed variables were age, metabolic profile including total cholesterol, triglycerides, HDL-C, blood sugar, total protein , albumine, urea, uric acid, Ca, Na, Cl, phosphate, heamatological parametes, zinc, copper and selenium. Descriptive statistics and testing of hypothesis were used for the analysis usingMeaną SD testP≤0.05. Results: lipid profile showed significant variability among studied group in this study, also fasting blood sugar showed significant differences between groups, serum estradiol highly increased in postmenapausal obese with breast cancer, significant hematological variations had been seen among studied groupps; serum cupper increased in obese breast cancer while zinc ,selenium decreased, serum k highly increased in postmenapausal obese breast cancer. Conclusions: From this study, we can interested with several mechanisms involved in pathogenesis of breast cancer, from which we can evaluate the treatment of breast cancer including hormonal therapy especially in obese postmenopausal women which may required modification in treatment protocols to improve outcomes .

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