FORMULATION AND EVALUATION OF ETHOSOMES OF CLOBETASOL PROPIONATE
Pandey Richa*, Sharma Dinesh Kumar and Singh Arun Kumar
ABSTRACT
Ethosomes are vesicular drug delivery systems. “Ethosomes are
ethanolic liposomes”. Ethosomes are lipid vesicular structure
containing phospholipids, alcohol in relatively high concentration,
propylene glycol and water. Ethosomes can entrap drug molecule of
various physicochemical characters such as hydrophilic, lipophilic or
amphiphilic in nature. The size range of ethosomes may variate from
tens of nanometers to microns. The advantage of ethosomes over other
topical delivery includes enhanced permeation of drug molecules to the
skin and through the skin to the systemic circulation. Better patient
compliance. Better stability and solubility of many drugs as compared
to conventional vesicles. Relatively smaller size as compared to
conventional vesicles. Composition and components of ethosomes are safe, they have various
applications in pharmaceutical, veterinary and cosmetic field. Clobetasol propionate is a
synthetic corticosteroid, for topical dermatologic use. It is derived from prednisolone with
low mineralocorticoid activity and high glucocorticoid activity. Corticosteroids are
therapeutic agents generally used in the treatment of skin disorders such as psoriasis and
eczema. As research shows that stratum corneum is the main barrier for topical absorption of
drug. Topical application of drug at pathological sites offers possible advantages of
delivering the drug directly to the site of action. The present study aim to formulate and
evaluate ethosomes of clobetasol propionate. Ethosomes of clobetasol propionate was
successfully prepared by cold method and characterized by pH, size, zeta potential, drug
content, drug entrapment, in-vitro drug release and formulation F9 was found to be best from
all the formulations prepared.
Keywords: Ethosomes, liposomses, ampiphillic, glucocorticoid, stratum corneum, topical, in-vitro.
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