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Abstract

MELATONIN MODULATES MERCURY INDUCED OXIDATIVE STRESS IN RAT LIVER

Tapan A. Patel* and Mandava V. Rao

ABSTRACT

Objective: The present work was aimed to assess the beneficial effect of melatonin against mercury induced oxidative stress in rat liver. Methods: Rats were divided into five groups and treated for 60 days. Group 1 served as control. Group 2 & 3 animals were treated with mercuric chloride (2 & 4mg/kg BW) orally. Group 4 animals were treated with melatonin (5mg/kg BW) intraperitoneally and Group 5 animals received melatonin with HgCl2. Various antioxidant indices assayed were superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathiones- transferase (GST), thiobarbituric acid-reactive substances (TBARS), total -SH, glutathione (GSH), protein carbonyl (PC), hydrogen peroxide (H2O2) and total ascorbic acid (TAA). Results: Treatment of HgCl2 caused significant (P<0.01, P<0.001) decrease in activities of SOD, CAT, GPx and GR as well as levels of total -SH, GSH, TAA and total proteins reduced significantly (P<0.001). Whereas, the levels of TBARS, PC and H2O2 showed significant elevation. Administration of melatonin with mercury mitigated significantly the decline in activities of SOD, CAT, GPx and GR as well as restored the levels of total -SH, GSH, TAA, total proteins, TBARS, PC and H2O2. Conclusion: The results concluded that melatonin supplementation modulated mercuric chloride induced hepatotoxicity.

Keywords: Melatonin, mercuric chloride, oxidative stress, hepatotoxicity, rat.


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