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Abstract

“SYNTHESIS AND ANTIOXIDANT, ANTIMICROBIAL ACTIVITY OF 9-SUBSTITUTED DERIVATIVES OF 6,7-DIHYDRO-6,6-DIMETHYL-9- (4'-PHENYL) TETRAZOLO[5,1-b]QUINAZOLIN-8(3H,5H,9H)-ONE.”

Vijay N. Bhosale*, Gopinath S. Khansole, Jaman A. Angulwar and Sunil S. Choudhare

ABSTRACT

A green, simple and efficient procedure has been developed for the synthesis of 9-substituted derivatives of 6,7-dihydro-6,6-dimethyl-9- (4'-phenyl) tetrazolo [5,1-b] quinazolin-8(3H,5H,9H)-one via a multicomponent one pot three molecule condensation of 1H-tetrazol- 5-amine, dimedone in acetonitrile and iodine with different substituted aromatic aldehyde . Newly synthesized tetrazolo[5,1-b] quinazolin- 8(3H,5H,9H)-one derivatives were screened for their antioxidant and antimicrobial activity.

Keywords: 1H-tetrazol-5-amine, Dimedone, Aromatic Aldehyde , Molecular iodine, MCR’s.


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