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Abstract

ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF ROOT EXTRACTS OF ERYTHRINA VARIEGATA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Jagdish Chandra Nagar* and Lalit Singh Chauhan

ABSTRACT

Hypoglycemic and hypolipidemic activity of alcohol and aqueous root extracts of Erythrina variegata Linn. is evaluated in streptozotocin induced diabetic rats. Diabetes was induced into albino Wistar rats by intraperitonial administration of streptozotocin (STZ, 50mg/kg). Blood samples were collected from overnight fasted normal and diabetic rats on 0th, 7th, 14th and 21st days of treatment. Hypoglycemic activity was evaluated by measuring serum glucose level and glycosylated haemoglobin level after dosing with 300 mg/kg and 600 mg/kg of both the extracts. Hypolipidemic activity was evaluated by measuring various biochemical parameters like total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein, high density lipoprotein and phospholipids. The results showed that the extracts significantly (P<0.001, p<0.01) reduced fasting blood glucose of streptozotocin diabetic rats in a dose-related manner, when compared to control and standard (Glibenclamide 500μg/kg). Both the extracts also have a significant recovery in the levels of parameters measured in lipid profile, when compared to control and standard group. Hence this plant may be a potential source for the isolation of new orally active agent(s) for diabetic mellitus. The present investigation established pharmacological evidence to support the folklore claim that it is used as hypoglycemic and hypolipidemic agent.

Keywords: Erythrina variegata, Streptozotocin, Glibenclamide, Diabetes.


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