WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

SPECTROPHOTOMETRIC KINETIC INVESTIGATION OF OXIDATION OF AMITRIPTYLINE BY N-BROMO-PBENZENESULPHONAMIDE IN ACIDIC BUFFER (pH= 1.2) MEDIUM

Chandrashekar*, R.T Radhika, B.M. Venkatesha, S. Ananda and V. R. Kattimani

ABSTRACT

Oxidation of amitriptyline by sodium N-bromobenzenesulphonamide (BAB) has been studied in acidic buffer medium pH 1.2 has been kinetically studied at 303K. Oxidation of amitriptyline was followed spectrophotometrically at λmax= 410 nm. The reaction rate shows a first order dependence on [oxidant], [substrate] and inverse fractional order dependence in [H+]. Addition of halide ions and the reduction product of benzenesulphonamide and variation of ionic strength and dielectric constant of the medium do not have any significant effect on the reaction rate. The reaction was studied at different temperatures and activation parameters were evaluated. Mechanisms proposed and the derived rate law is consistent with the observed kinetics.

Keywords: Oxidation, Amitriptyline, Bromamine-B, acidic buffer, kinetics.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More