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Abstract

STUDY OF TOXICITY PARAMETERS ON COMBINED HERBAL EXTRACT OF ASYSTASIA GANGETICA, FICUS RECEMOSA AND MORUS INDICA USING EXPERIMENTAL RATS.

Somanathan S.S.*, Ranganayakulu D. and Jayaveera K.N.

ABSTRACT

Aim of this study is to create a data on the safety and toxic levels of this combined extract preparation for further screenings and usages. Mostly single plant extract toxicity and safety study is being done, but required data for this combined extract preparation-OECD 425 guideline is followed to conduct toxicity effect for this study. This guideline was preferred to conduct the toxicity, due to 1) minimize the number of animals to estimate LD50 and confidential interval (CI). estimation. 2) also the guideline OECD 425 was concurrently under taken with revision of test guidelines 420 and 423 for oral toxicity testing. The ethanolic extract of Asystasia gangetica (A- Acanthacaea), Ficus recemosa (F-Moraceae) and Morus indica (M-Moraceae) evaluated for acute toxicity (AFM) in adult wistar rats. The ethanolic extract of AFM (A+F+M) was administered as 175(50+60+65)mg, 500(150+175+175)mg, 1500(450+525+525)mg and 5000(1500+1700+1750)mg. The first group animal is dosed a step below (~ly,-3.2 factor) the best preliminary estimation of LD 50 (<5000mg) the moribund (nearing to death stage) was observed and the dose was reduced to 3.2 factor level i.e., 5000mg/kg as combination as 175, 500, 1500, 5000, since the dosing in standard from 175mg/kg due to no estimation of the substandard lethality is available. The final results were statistically analyzed after 14days and tabulated. The results revealed that no abnormalities in treated animals were found than the control animals.

Keywords: Safety, toxicity, combined extract, OECD 425, Asystasia gangetica, Ficus recemosa, Morus indica.


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