WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF LOVASTATIN TRANSFERSOMAL LOADED GELS FOR TRANSDERMAL DRUG DELIVERY

V. Lakshmi Narasaiah*, Dr.P.Padmabhushanam, Dr. V. Sai Kishore

ABSTRACT

The objective of the present study was to develop the controlled release transdermal drug delivery systems of Lovastatin using transfersomes incorporated in gels, which will control the release of drug, increasing the bioavailability of the drug and thus decreasing the dosing frequency of the drug. It was investigated by encapsulating the drug in various transfersomal formulations composed of various ratios of Soya Lecithin: Span 80 or Tween 80 or sodium deoxycholate prepared by rotary evaporation sonication method. Lipid:surfactant ratio of 90:10 is more effective when compared to other ratios. Experimental results of the present study showed that deformable lipid vesicles improve the transdermal delivery, prolong the release, and improve the site specificity of the lipophilic model drug, Lovastatin. The drug diffusion studies showed that a Transfersome vesicle follows zero order kinetics and mechanism of release follows peppas model.

Keywords: film hydration method, Anti-hyperlipidemic, Controlled release, Lipid, Surfactant.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More