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Abstract

A REVIEW ON THERAPEUTICAL AND TOXICOLOGICAL EVENTS OF ANTIBIOTIC IN PREGNANCY

Muhammad Abbas*, Md. Ariful Islam, Abdullahi Ayuba, Debanjan Das,
Md. Akabar Ansari and Akriti Nepal

ABSTRACT

Even though pregnancy is regarded as a physiological state. At the time of pregnancy, there are some untreated sexually transmitted or urinary tract infections that associated with important morbidity, such as low birth weight, preterm birth and spontaneous abortion. It is estimated that one in four women will be prescribed an antibiotic at the time of pregnancy, analyzing almost 80% of pregnant women that prescribed the medication. In addition World Health Assembly expressed serious concern regarding antibiotic resistance due to antibiotic overuse and misuse and urged immediate action to combat antibiotic resistance on a global scale. Some of Antibiotic that have been related to pregnancy are associated with both short-term e.g., congenital abnormalities and long-term effect e.g., changes in gut micro biome, asthma, atopic dermatitis in the newborn. In addition, it is approximately that only 10% of medications have enough related data to safe and effective use in pregnancy. Antibiotics such as beta-lactams, vancomycin, nitrofurantoin, metronidazole, clindamycin and fosfomycin are mostly regarded as safe and effective in pregnancy. Fluoroquinolones and tetracyclines are generally shunned out in pregnancy. Physiologic changes in pregnancy lead to an increase in glomerulars filtration rate, increase in total body volume and enhanced cardiac output. These changes may lead to pharmacokinetic alterations in antibiotics that require dose adjustment or careful monitoring and assessment.

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