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Abstract

CURRENT SCENARIO ON USE OF ISOTRETINOIN IN VARIOUS FORMS OF ACNE

Dr. Nalini Negi*, Dr. Sumir Kumar, Sourabh Kosey and Tarun Gautam

ABSTRACT

Acne is estimated to affect 9.4% of the population globally in which it is commonly seen in post pubescent teens, predominantly in males.[1] Across gender females (56%) showed significantly higher prevalence than males (51.6%), alongside males showing higher incidence than females in onset of disease at younger age. In case of mild acne condition females significantly showed higher prevalence than males, while in case of moderate and severe condition it was observed to be common in males than females.[2] To paramount the prevalence and severity of acne vulgaris in adolescents, a cross-sectional, study was performed that was community-based. In it, 1,002 people with an age of 16±0.9 years were volunteered. In the study the prevalence rate was 93.3; 94.4% and 92.0% for boys and girls respectively among which 14% of the members had moderate to severe acne. Here, the prevalence of moderate to severe acne was 19.9% in those with and 9.8% in those without a family history of acne (P<0.0005; OR: 2.3).[3] According to a past study, the prevalence of facial acne in 15–25 years of age group was 91.3% (95% CI 88.9–93.7). Another study was done to exhibit the occurrence of acne due to increased sebum production, shown 91.3%, of the prevalence rate.[4] Throughout the age from third decade the etiology of acne appear to be changed in adulthood. The prevalence rate is higher in post-adolescent women, in distinction to a high prevalence in adolescent male.[5] As isotretinoin has teratogenic effect, so female patients on the therapy of isotretinoin that are clinged to multiple contraception mehods should strictly be forewarned not to be pregnant. In a cohort study, it has been demonstrated that out of 8609 women, 210 were pregnant during the therapeutic regimen of isotretinoin: 68 were pregnant at the time when they started their therapy on isotretinoin (32%), 90 became pregnant at that period when they were taking isotretinoin (43%) and 52 became pregnant on discontinuation of isotretinoin (25%).[6] The isotretinoin therapy within the first trimester have been related with congenital malformations.[7]

Keywords: Isotretinoin, teratogenic, acne, retinoids, iPLEDGE.


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