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Abstract

REMARKABLE UTILITY OF AROMATIC ALDEHYDES, HALOGENS AND CYANO GROUPS IN THE SYNTHESIS OF PHARMACOLOGI- CALLY SIGNIFICANT COMPOUNDS: A REVIEW

Pradeep K. Soni*, Anand K. Halve and Chandrakant P. Shinde

ABSTRACT

Synthetic utility of aromatic aldehydes is well known since these played an important role in the synthesis of dyes, chemotherapeutic agents, analytical reagents and variety of compounds. These are important and versatile intermediates in the pharmaceutical industry and organic synthesis. Considerable interest attached with the compounds bearing cyano moiety because they have been used widely as precursors for pharmaceuticals, heterocyclic compounds and biologically active molecules. Compounds with halogen atoms have become of immense importance in the pharmaceutical and agrochemical products. Present communication is an attempt to review the reports on the synthesis of pharmacologically active compounds of non Schiff base or non β-lactams using aromatic aldehydes, halogens and cyano groups.

Keywords: Aromatic aldehydes, tertiaryaminobenzaldehydes, halogen, cyanoethylation and cyano group.


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