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Vydehi Maheshwaram* and Pravalika Raavi


In-situ gel, or in vivo gel, environment sensitive gel, is a new dosage form which has been applied as nasal drug delivery. Nasal route has been explored widely for delivery of a large number of drug molecules, owing to its rich vasculature and thin epithelial lining. When a drug is administered via nasal route it directly reaches systemic circulation and provides rapid onset of action. Compared with liquid nasal formulations, nasal in situ gels are instilled as low viscosity solutions into the nasal cavity and upon contact with the nasal mucosa, the polymer changes conformation producing a gel, so it cannot only prolong the contact time between the drug and the absorptive sites in the nasal cavity, but also release drug slowly and continuously. The phase transition can be induced by a shift in pH, a shift in temperature or by the presence of cations. The prepared gels were characterized for physical appearance, pH, solution viscosity, drug content, In vitro drug release studies were conducted in Simulated nasal fluid PH and drug was analyzed by UV spectrophotometry. Diffusion data were fitted to various models to ascertain kinetics and mechanism of drug release from gels. Fourier Transform Infra Red (FTIR) spectra of the optimized formulations revealed no drug excipient interaction.

Keywords: Insitu gel, Nasal drug delivery, Phase transition, Nasal Cavity.

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