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Abstract

USE OF BIFIDOBACTERIUM FOR TREATMENT AND PROTECTIVE FROM ENTAMOEBA HISTOLYTICA INFECTION IN MICE

*Sabaa T. Mohamed

ABSTRACT

This study describes the in vivo effect of Bifidobacteria in Entamoeba histolytica infected BALB/c mice. Experimentally, It was noticed that daily administration live Bifidobacteria cells in 7 days prior to challenge with Entamoeba histolytica was efficiently reduce severity of infection in mice, and resolution infection was occurred in day 8th post inoculation ,with efficacy treated (75.63%) ,also excretion of histolytica cysts were significantly reduced in probiotic-treated groups ,and infection completely end in day 10 post-inoculation ,with efficacy treated(67.86%). It was very clear that histolytica cysts decreased in metronidazole treated group with efficacy(67.56%), but infection remained until 9th day post inoculation, compared with controlled mice remained excretion of histolytica cysts through all experimental period. Histolopathological study showed that probiotic administration also induce intestinal lymph node proliferation. The data demonstrates the anti-histolytical effect of probiotic in vivo by inhibiting the colonization of histolytica trophozoites and there reducing the severity of histolytica infection.

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