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Abstract

SIMPLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF PAROXETINE IN TABLETS USING CHLORANILIC ACID AS CHROMOGENIC REAGENT

Nwodo Ngozi Justina*, Ibezim Akachukwu

ABSTRACT

Spectrophotometric analysis of Paroxetine-chloranilic acid complex was studied. Stable and instantaneous purple complex was formed on mixing Paroxetine solution with chloranilic acid in dioxin at ambient temperature. The Job’s plot of continuous variation method indicated 2:1 stoichiometry for the interaction and the product exhibited maximum absorption band at 540 nm. The complexation attained equilibrium after 10 minutes from time of mixing and was found to be stable over a period of 2 hrs. Beer’s law was obeyed over the concentration range of 5 – 40 μg/ml. The assay limits of detection and quantitation were 0.24 and 0.91 μg/ml respectively. The precision of the method and the values of relative standard deviation never exceeded 2%. No interference was observed from the excipients commonly present in dosage form. The proposed method was successfully applied to the analysis of Paroxetine in pure and pharmaceutical dosage forms with good accuracy, precision and reproducibility.

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