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Abstract

DEVELOPMENT AND VALIDATION OF DIFFERENCE SPECTROSCOPIC METHOD FOR DETERMINATION OF BUPROPION IN ITS TABLET DOSAGE FORM

Patel Neelam*, Vaghela Pooja and Sanjay Gohil

ABSTRACT

A simple, accurate & precise difference spectroscopy method was developed for determination of Bupropion in its pharmaceutical dosage form. The proposed method depends upon measuring the amplitude of absorbance on difference spectra of Bupropion in 0.001N NaOH and 0.001N HCl at 234nm and 254nm respectively. The calibration curve linear over the range 2.5-30 μg/ml with correlation coefficient (r) 0.9998. The percentage of recovery found to be 99.20-98.30%. The developed method validated statistically and was applied successfully for routine analysis of Bupropion in its Tablet Dosage form.

Keywords: Bupropion, Difference spectroscopy, Antidepressant.


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